CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape

Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for the treatment of hematological malignancies. However, in patients with solid tumors, objective responses to CAR-T cell therapy remain sporadic and transient. A major obstacle for CAR-T cells is the intrinsic a...

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Bibliographic Details
Main Authors: Alba Rodriguez-Garcia, Asis Palazon, Estela Noguera-Ortega, Daniel J. Powell, Sonia Guedan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptors (CAR)
solid tumors
immunotherapy
immunosuppressive tumor microenvironment
adoptive cell transfer (ACT)
inhibitory receptors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01109/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01109/full

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