CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape
Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for the treatment of hematological malignancies. However, in patients with solid tumors, objective responses to CAR-T cell therapy remain sporadic and transient. A major obstacle for CAR-T cells is the intrinsic a...
Main Authors: | Alba Rodriguez-Garcia, Asis Palazon, Estela Noguera-Ortega, Daniel J. Powell, Sonia Guedan |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-06-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01109/full |
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