Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19

Pluripotent stem cells can be stabilized in vitro at different developmental states by the use of specific chemicals and soluble factors, of which the naïve and primed states are the best characterized. Naïve pluripotent stem cells (PSCs) correspond to the early pre-implantation blastocyst and, in m...

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Bibliographic Details
Main Authors: Raquel Bernad, Cian J. Lynch, Rocio G. Urdinguio, Camille Stephan-Otto Attolini, Mario F. Fraga, Manuel Serrano
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/10/4/876