Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation

Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation

Activation of γ-aminobutyric acid (GABAA) receptors have been associated with the onset of epileptiform events. To investigate if a causal relationship exists between GABAA receptor activation and ictal event onset, we activated inhibitory GABAergic networks in the superficial layer (2/3) of the som...

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Bibliographic Details
Main Authors: Michael Chang, Joshua A. Dian, Suzie Dufour, Lihua Wang, Homeira Moradi Chameh, Meera Ramani, Liang Zhang, Peter L. Carlen, Thilo Womelsdorf, Taufik A. Valiante
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Neurobiology of Disease
Subjects:
Interictal events
Ictal events
Seizures
GABA
Interneurons
Optogenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302255

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http://www.sciencedirect.com/science/article/pii/S0969996117302255

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