HLA-C downregulation by HIV-1 adapts to host HLA genotype.

HLA-C downregulation by HIV-1 adapts to host HLA genotype.

HIV-1 can downregulate HLA-C on infected cells, using the viral protein Vpu, and the magnitude of this downregulation varies widely between primary HIV-1 variants. The selection pressures that result in viral downregulation of HLA-C in some individuals, but preservation of surface HLA-C in others ar...

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Bibliographic Details
Main Authors: Nathaniel D Bachtel, Gisele Umviligihozo, Suzanne Pickering, Talia M Mota, Hua Liang, Gregory Q Del Prete, Pramita Chatterjee, Guinevere Q Lee, Rasmi Thomas, Mark A Brockman, Stuart Neil, Mary Carrington, Bosco Bwana, David R Bangsberg, Jeffrey N Martin, Esper G Kallas, Camila S Donini, Natalia B Cerqueira, Una T O'Doherty, Beatrice H Hahn, R Brad Jones, Zabrina L Brumme, Douglas F Nixon, Richard Apps
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007257

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https://doi.org/10.1371/journal.ppat.1007257

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