Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern transmissibility, responsiveness to vaccination, and disease severity. In a screen for new models of SARS-CoV-2 infection, we identify human H522 lung adenocarcinoma cells as naturally permissive to SARS-...

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Bibliographic Details
Main Authors: Maritza Puray-Chavez, Kyle M. LaPak, Travis P. Schrank, Jennifer L. Elliott, Dhaval P. Bhatt, Megan J. Agajanian, Ria Jasuja, Dana Q. Lawson, Keanu Davis, Paul W. Rothlauf, Zhuoming Liu, Heejoon Jo, Nakyung Lee, Kasyap Tenneti, Jenna E. Eschbach, Christian Shema Mugisha, Emily M. Cousins, Erica W. Cloer, Hung R. Vuong, Laura A. VanBlargan, Adam L. Bailey, Pavlo Gilchuk, James E. Crowe, Jr., Michael S. Diamond, D. Neil Hayes, Sean P.J. Whelan, Amjad Horani, Steven L. Brody, Dennis Goldfarb, M. Ben Major, Sebla B. Kutluay
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
SARS-CoV-2
COVID-19
ACE2-independent
type I interferon
RIG-I-like receptors
virus-host interactions
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007622

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