Impact of cellular microenvironment and mechanical perturbation on calcium signalling in meniscus fibrochondrocytes

Impact of cellular microenvironment and mechanical perturbation on calcium signalling in meniscus fibrochondrocytes

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Mechanical signals regulate a multitude of cell functions and ultimately govern fibrous tissue growth, maintenance and repair. Such mechanotransduction processes often involve modulation of intracellular calcium concentration ([Ca2+]i). However, most studies interrogate these responses in cells in s...

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Bibliographic Details
Main Authors: WM Han, S-J Heo, TP Driscoll, ME Boggs, RL Duncan, RL Mauck, DM Elliott
Format: Article
Language:English
Published: AO Research Institute Davos 2014-06-01
Series:European Cells & Materials
Subjects:
Meniscus
fibrochondrocytes
microenvironment
tensile strain
intracellular calcium
oscillation
aligned scaffold
silicone membrane
mechanotransduction
fibrous tissues
Online Access:http://www.ecmjournal.org/journal/papers/vol027/pdf/v027a23.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol027/pdf/v027a23.pdf

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