Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat.

Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat.

SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella. A significant number of Spag6-deficient mice die with hydrocephalus, and surviving males are sterile because of sperm motility defects. In further exploring the ciliary dysfunction in S...

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Bibliographic Details
Main Authors: Maria E Teves, Patrick R Sears, Wei Li, Zhengang Zhang, Waixing Tang, Lauren van Reesema, Richard M Costanzo, C William Davis, Michael R Knowles, Jerome F Strauss, Zhibing Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4204823?pdf=render

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http://europepmc.org/articles/PMC4204823?pdf=render

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