FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging

FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging

Ageing leads to a loss of muscle mass and strength, called sarcopenia. Here, the authors show that fatty acid binding protein 3 (FABP3), a lipid chaperone, drives age-dependent lipidome remodeling in skeletal muscle and deteriorates muscle mass and contractility by modulating membrane fluidity and E...

Full description

Bibliographic Details
Main Authors: Seung-Min Lee, Seol Hee Lee, Youngae Jung, Younglang Lee, Jong Hyun Yoon, Jeong Yi Choi, Chae Young Hwang, Young Hoon Son, Sung Sup Park, Geum-Sook Hwang, Kwang-Pyo Lee, Ki-Sun Kwon
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19501-6

Internet

https://doi.org/10.1038/s41467-020-19501-6

Similar Items