HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
Type I Interferon is thought to be a driving force for immune activation and T cell exhaustion during HIV infection. Here the authors show that intron-containing HIV RNA induces innate immune activation resulting in associated T cell dysfunction.
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-05899-7 |