New Cardenolides from Biotransformation of Gitoxigenin by the Endophytic Fungus <i>Alternaria eureka</i> 1E1BL1: Characterization and Cytotoxic Activities

New Cardenolides from Biotransformation of Gitoxigenin by the Endophytic Fungus <i>Alternaria eureka</i> 1E1BL1: Characterization and Cytotoxic Activities

Microbial biotransformation is an important tool in drug discovery and for metabolism studies. To expand our bioactive natural product library via modification and to identify possible mammalian metabolites, a cytotoxic cardenolide (gitoxigenin) was biotransformed using the endophytic fungus <i&g...

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Bibliographic Details
Main Authors: Erdal Bedir, Çiğdem Karakoyun, Gamze Doğan, Gülten Kuru, Melis Küçüksolak, Hasan Yusufoğlu
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
<i>Nerium oleander</i> L.
cardenolides
oleandrin
gitoxigenin
biotransformation
endophytic fungus
Online Access:https://www.mdpi.com/1420-3049/26/10/3030

Internet

https://www.mdpi.com/1420-3049/26/10/3030

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