Insights From Molecular Dynamics Simulations of a Number of G-Protein Coupled Receptor Targets for the Treatment of Pain and Opioid Use Disorders

Insights From Molecular Dynamics Simulations of a Number of G-Protein Coupled Receptor Targets for the Treatment of Pain and Opioid Use Disorders

Effective treatments for pain management remain elusive due to the dangerous side-effects of current gold-standard opioid analgesics, including the respiratory depression that has led to skyrocketing death rates from opioid overdoses over the past decade. In an attempt to address the horrific opioid...

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Bibliographic Details
Main Authors: João Marcelo Lamim Ribeiro, Marta Filizola
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GPCRs
opioid crisis
molecular dynamics
pain
opioid use disorder
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00207/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00207/full

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