Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

Abstract Background There is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction, a proposed disease mechanism in COPD, is associated with the release of mitochondrial DNA (mtDNA), but plasma cell-free mtDNA has not be...

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Bibliographic Details
Main Authors: William Z. Zhang, Katherine L. Hoffman, Kristen T. Schiffer, Clara Oromendia, Michelle C. Rice, Igor Barjaktarevic, Stephen P. Peters, Nirupama Putcha, Russell P. Bowler, J. Michael Wells, David J. Couper, Wassim W. Labaki, Jeffrey L. Curtis, Meilan K. Han, Robert Paine, Prescott G. Woodruff, Gerard J. Criner, Nadia N. Hansel, Ivan Diaz, Karla V. Ballman, Kiichi Nakahira, Mary E. Choi, Fernando J. Martinez, Augustine M. K. Choi, Suzanne M. Cloonan
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Respiratory Research
Subjects:
COPD
Mitochondrial dysfunction
mtDNA
SPIROMICS
Online Access:https://doi.org/10.1186/s12931-021-01707-x

Internet

https://doi.org/10.1186/s12931-021-01707-x

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