An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling.

An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling.

Lung cancer is emerging rapidly as the leading death cause in Chinese cancer patients. The causal factors for Chinese lung cancer development remain largely unclear. Here we employed an shRNA library-based loss-of-function screen in a genome-wide and unbiased manner to interrogate potential tumor su...

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Bibliographic Details
Main Authors: Hui Xu, Huiying Sun, Haiyuan Zhang, Jiawei Liu, Fangfang Fan, Yilan Li, Xuelian Ning, Yue Sun, Shaochun Dai, Baogang Liu, Min Gao, Songbin Fu, Chunshui Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4427398?pdf=render

Internet

http://europepmc.org/articles/PMC4427398?pdf=render

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