Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan

Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan

MiR-430 is considered an important regulator during embryonic development, but genetic loss-of-function study is still lacking. Here we demonstrated that genetic deletion of the miR-430 cluster resulted in developmental defects in cell movement, germ layer specification, axis patterning and organ pr...

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Bibliographic Details
Main Authors: Yun Liu, Zeyao Zhu, Idy H. T. Ho, Yujian Shi, Jianzhen Li, Xia Wang, Matthew T. V. Chan, Christopher H. K. Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Genetics
Subjects:
small regulatory RNAs
miR-430
genome editing
gastrulation
cell fate
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00853/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00853/full

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