Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction

Abstract Background Metastases are the leading cause of breast cancer-related deaths. The tumor microenvironment impacts cancer progression and metastatic ability. Fibrillar collagen, a major extracellular matrix component, can be studied using the light scattering phenomenon known as second-harmoni...

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Bibliographic Details
Main Authors: Danielle E. Desa, Robert L. Strawderman, Wencheng Wu, Robert L. Hill, Marcel Smid, J. W. M. Martens, Bradley M. Turner, Edward B. Brown
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12885-020-07713-4