Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.

As primary p53 antagonists, Mdm2 and the closely related Mdm4 are relevant cancer therapeutic targets. We have previously described a series of cell-permeable stapled peptides that bind to Mdm2 with high affinity, resulting in activation of the p53 tumour suppressor. Within this series, highest affi...

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Bibliographic Details
Main Authors: Sharon Min Qi Chee, Jantana Wongsantichon, Jiawei Siau, Dawn Thean, Fernando Ferrer, Robert C Robinson, David P Lane, Christopher J Brown, Farid J Ghadessy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5724825?pdf=render

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http://europepmc.org/articles/PMC5724825?pdf=render

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