Embryonic senescence and laminopathies in a progeroid zebrafish model.

Embryonic senescence and laminopathies in a progeroid zebrafish model.

BACKGROUND: Mutations that disrupt the conversion of prelamin A to mature lamin A cause the rare genetic disorder Hutchinson-Gilford progeria syndrome and a group of laminopathies. Our understanding of how A-type lamins function in vivo during early vertebrate development through aging remains limit...

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Bibliographic Details
Main Authors: Eriko Koshimizu, Shintaro Imamura, Jie Qi, Jamal Toure, Delgado M Valdez, Christopher E Carr, Jun-ichi Hanai, Shuji Kishi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3068137?pdf=render

Internet

http://europepmc.org/articles/PMC3068137?pdf=render

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