IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined. By stimulating mouse macrophages with a titration matrix of TLR ligand pairs, we...

Full description

Bibliographic Details
Main Authors: Rachel A Gottschalk, Michael G Dorrington, Bhaskar Dutta, Kathleen S Krauss, Andrew J Martins, Stefan Uderhardt, Waipan Chan, John S Tsang, Parizad Torabi-Parizi, Iain DC Fraser, Ronald N Germain
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
inflammation
macrophage
type I IFN
negative feedback
signal integration
Online Access:https://elifesciences.org/articles/46836

Internet

https://elifesciences.org/articles/46836

Similar Items