Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma

Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma

Summary: Many metabolic pathways, including lipid metabolism, are rewired in tumors to support energy and biomass production and to allow adaptation to stressful environments. Neuroblastoma is the second deadliest solid tumor in children. Genetic aberrations, as the amplification of the MYCN-oncogen...

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Bibliographic Details
Main Authors: María Victoria Ruiz-Pérez, Lourdes Sainero-Alcolado, Ganna Oliynyk, Isabell Matuschek, Nicola Balboni, S.J. Kumari A. Ubhayasekera, Marteinn Thor Snaebjornsson, Kamil Makowski, Kristina Aaltonen, Daniel Bexell, Dolors Serra, Roland Nilsson, Jonas Bergquist, Almut Schulze, Marie Arsenian-Henriksson
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:iScience
Subjects:
biological sciences
molecular biology
cell biology
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221000961

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http://www.sciencedirect.com/science/article/pii/S2589004221000961

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