The Plasma Factor XIII Heterotetrameric Complex Structure: Unexpected Unequal Pairing within a Symmetric Complex

The Plasma Factor XIII Heterotetrameric Complex Structure: Unexpected Unequal Pairing within a Symmetric Complex

Factor XIII (FXIII) is a predominant determinant of clot stability, strength, and composition. Plasma FXIII circulates as a pro-transglutaminase with two catalytic A subunits and two carrier-protective B subunits in a heterotetramer (FXIII-A<sub>2</sub>B<sub>2</sub>). FXIII-A...

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Bibliographic Details
Main Authors: Sneha Singh, Alexis Nazabal, Senthilvelrajan Kaniyappan, Jean-Luc Pellequer, Alisa S. Wolberg, Diana Imhof, Johannes Oldenburg, Arijit Biswas
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Biomolecules
Subjects:
coagulation factor xiii complex
threaded modeling
cross-linking mass spectrometry
haddock flexible docking
molecular dynamics simulation
atomic force microscopy
isothermal titration calorimetry
Online Access:https://www.mdpi.com/2218-273X/9/12/765

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https://www.mdpi.com/2218-273X/9/12/765

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