The Plasma Factor XIII Heterotetrameric Complex Structure: Unexpected Unequal Pairing within a Symmetric Complex
Factor XIII (FXIII) is a predominant determinant of clot stability, strength, and composition. Plasma FXIII circulates as a pro-transglutaminase with two catalytic A subunits and two carrier-protective B subunits in a heterotetramer (FXIII-A<sub>2</sub>B<sub>2</sub>). FXIII-A...
Main Authors: | Sneha Singh, Alexis Nazabal, Senthilvelrajan Kaniyappan, Jean-Luc Pellequer, Alisa S. Wolberg, Diana Imhof, Johannes Oldenburg, Arijit Biswas |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-11-01
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Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/9/12/765 |
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