NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease

NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease

NOTCH intercellular signaling mediates the communications between adjacent cells involved in multiple biological processes essential for tissue morphogenesis and homeostasis. The NOTCH1 mutations are the first identified human genetic variants that cause congenital bicuspid aortic valve (BAV) and ca...

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Bibliographic Details
Main Authors: Yidong Wang, Yuan Fang, Pengfei Lu, Bingruo Wu, Bin Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
NOTCH
aortic valve development
calcific aortic valve disease
EMT
bicuspid aortic valve
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.682298/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.682298/full

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