IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors

IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors

<p>Abstract</p> <p>Background</p> <p>Hepatoblastoma (HB) is an embryonal liver neoplasm of early childhood with a poor prognosis for patients with distant metastases and vascular invasion. We and others have previously shown that the overexpression of <it>insulin-...

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Bibliographic Details
Main Authors: Regel Ivonne, Eichenmüller Melanie, Joppien Saskia, Liebl Johanna, Häberle Beate, Müller-Höcker Josef, Vollmar Angelika, von Schweinitz Dietrich, Kappler Roland
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Molecular Cancer
Subjects:
Hepatoblastoma
Epigenetics
Methylation
Invasion
IGF2
Online Access:http://www.molecular-cancer.com/content/11/1/9

Internet

http://www.molecular-cancer.com/content/11/1/9

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