The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium

The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium

Abstract Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction. Airway obstruction can cause airflow restriction and obstructive ventilation dysfunction. Cu...

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Bibliographic Details
Main Authors: Yidan Ren, Yi Zhang, Lixia Fan, Qinlian Jiao, Yunshan Wang, Qin Wang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Respiratory Research
Subjects:
CUL4A
Chronic obstructive pulmonary disease
Small airway epithelial cells
Epithelial-mesenchymal transition
Cigarette smoke
Online Access:http://link.springer.com/article/10.1186/s12931-019-1048-4

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http://link.springer.com/article/10.1186/s12931-019-1048-4

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