Modulating NMDA receptors to treat MK-801-induced schizophrenic cognition deficit: effects of clozapine combining with PQQ treatment and possible mechanisms of action

Modulating NMDA receptors to treat MK-801-induced schizophrenic cognition deficit: effects of clozapine combining with PQQ treatment and possible mechanisms of action

Abstract Background Clozapine has remarkable efficacy on both negative and cognitive symptoms of schizophrenia due to its slight activation of NMDA receptor. In fact, much evidence to the contrary. NMDAR is a complex containing specific binding sites, which are regulated to improve negative symptoms...

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Bibliographic Details
Main Authors: Xingqin Zhou, Gangming Cai, Shishi Mao, Dong Xu, Xijie Xu, Rongjun Zhang, Zhiwen Yao
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Psychiatry
Subjects:
Schizophrenic cognition deficit
NMDA receptor
GSK-3β/Akt signaling pathway
Apoptosis
PQQ combined with clozapine
Online Access:http://link.springer.com/article/10.1186/s12888-020-02509-z

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http://link.springer.com/article/10.1186/s12888-020-02509-z

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