Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model.

Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model.

Metastasis and disease relapse are hypothesized to result from tumor initiating cells (TICs). Previously, we have defined a CD44+/CD24-/low mammosphere-forming tumorigenic 493-gene signature in breast cancer. Stat3 was identified as a critical node in self-renewal based on an ongoing lentiviral shRN...

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Bibliographic Details
Main Authors: Bhuvanesh Dave, Melissa D Landis, David J Tweardy, Jenny C Chang, Lacey E Dobrolecki, Meng-Fen Wu, Xiaomei Zhang, Thomas F Westbrook, Susan G Hilsenbeck, Dan Liu, Michael T Lewis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3412855?pdf=render

Internet

http://europepmc.org/articles/PMC3412855?pdf=render

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