A zebrafish forward genetic screen identifies an indispensable threonine residue in the kinase domain of PRKD2

A zebrafish forward genetic screen identifies an indispensable threonine residue in the kinase domain of PRKD2

Protein kinase D2 belongs to a family of evolutionarily conserved enzymes regulating several biological processes. In a forward genetic screen for zebrafish cardiovascular mutants, we identified a mutation in the prkd2 gene. Homozygous mutant embryos develop as wild type up to 36 h post-fertilizatio...

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Bibliographic Details
Main Authors: Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
Format: Article
Language:English
Published: The Company of Biologists 2021-03-01
Series:Biology Open
Subjects:
protein kinase d2
cardiovascular development
cardiac valves
zebrafish
Online Access:http://bio.biologists.org/content/10/3/bio058542

Internet

http://bio.biologists.org/content/10/3/bio058542

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