Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita

Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita

Because of the morbidity and limited therapeutic options of autoimmune diseases, there is a high, and thus far, unmet medical need for development of novel treatments. Pemphigoid diseases, such as epidermolysis bullosa acquisita (EBA), are prototypical autoimmune diseases that are caused by autoanti...

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Bibliographic Details
Main Authors: Unni K. Samavedam, Nina Mitschker, Anika Kasprick, Katja Bieber, Enno Schmidt, Tamás Laskay, Andreas Recke, S. Goletz, Gestur Vidarsson, Franziska S. Schulze, Mikko Armbrust, Katharina Schulze Dieckhoff, Hendri H. Pas, Marcel F. Jonkman, Kathrin Kalies, Detlef Zillikens, Yask Gupta, Saleh M. Ibrahim, Ralf J. Ludwig
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
skin
autoimmunity
spleen tyrosine kinase
signal transduction
animal models
treatment
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00249/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00249/full

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