Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI).

Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI).

Brain phenotypes showing environmental influence may help clarify unexplained associations between urban exposure and psychiatric risk. Heritable prefrontal fMRI activation during working memory (WM) is such a phenotype. We hypothesized that urban upbringing (childhood urbanicity) would alter this p...

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Bibliographic Details
Main Authors: Jessica L Reed, Enrico D'Ambrosio, Stefano Marenco, Gianluca Ursini, Amanda B Zheutlin, Giuseppe Blasi, Barbara E Spencer, Raffaella Romano, Jesse Hochheiser, Ann Reifman, Justin Sturm, Karen F Berman, Alessandro Bertolino, Daniel R Weinberger, Joseph H Callicott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5892884?pdf=render

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http://europepmc.org/articles/PMC5892884?pdf=render

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