Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells

Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells

JAK2-V617F plays a key role in the pathogenesis of myeloproliferative neoplasm. However, its inhibitor ruxolitinib has shown limited clinical efficacies because of the ruxolitinib-persistent proliferation of JAK2-V617F-positive cells. We here demonstrate that the USP9X inhibitor WP1130 or EOAI340214...

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Bibliographic Details
Main Authors: Hiroki Akiyama, Yoshihiro Umezawa, Daisuke Watanabe, Keigo Okada, Shinya Ishida, Ayako Nogami, Osamu Miura
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
jak2-v617f
usp9x
wp1130
ruxolitinib
myeloproliferative neoplasms
bh3 mimetics
oxidative stress
Online Access:https://www.mdpi.com/2072-6694/12/2/406

Internet

https://www.mdpi.com/2072-6694/12/2/406

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