Implication of lipoprotein associated phospholipase A2 activity in oxLDL uptake by macrophages

Implication of lipoprotein associated phospholipase A2 activity in oxLDL uptake by macrophages

Recognition and uptake of oxidized LDL (oxLDL) by scavenger receptors of macrophages and foam cell formation are mediated by the oxidatively modified apolipoprotein B (ApoB) and lipid moiety of oxLDL. A great amount of oxidized phosphatidylcholine (oxPC) of oxLDL is hydrolyzed at the sn-2 position b...

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Bibliographic Details
Main Authors: Konstantinos P. Markakis, Maria K. Koropouli, Stavroula Grammenou-Savvoglou, Ewoud C. van Winden, Andromaxi A. Dimitriou, Constantinos A. Demopoulos, Alexandros D. Tselepis, Eleni E. Kotsifaki
Format: Article
Language:English
Published: Elsevier 2010-08-01
Series:Journal of Lipid Research
Subjects:
oxidized 1-palmitoyl-2-arachidonoyl-phosphatidylcholine
lysophosphatidylcholine
moderately oxidized LDL
heavily oxidized LDL
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520370553

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http://www.sciencedirect.com/science/article/pii/S0022227520370553

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