AMYCO: evaluation of mutational impact on prion-like proteins aggregation propensity

AMYCO: evaluation of mutational impact on prion-like proteins aggregation propensity

Abstract Background Around 1% of human proteins are predicted to contain a disordered and low complexity prion-like domain (PrLD). Mutations in PrLDs have been shown promote a transition towards an aggregation-prone state in several diseases. Results Recently, we have shown that an algorithm that co...

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Bibliographic Details
Main Authors: Valentin Iglesias, Oscar Conchillo-Sole, Cristina Batlle, Salvador Ventura
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Bioinformatics
Subjects:
Prion-like domain
Protein aggregation
Amyloid
Protein mutation
Online Access:http://link.springer.com/article/10.1186/s12859-019-2601-3

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http://link.springer.com/article/10.1186/s12859-019-2601-3

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