The gene expression response of chronic lymphocytic leukemia cells to IL-4 is specific, depends on ZAP-70 status and is differentially affected by an NFκB inhibitor.

The gene expression response of chronic lymphocytic leukemia cells to IL-4 is specific, depends on ZAP-70 status and is differentially affected by an NFκB inhibitor.

Interleukin 4 (IL-4), an essential mediator of B cell development, plays a role in survival of chronic lymphocytic leukemia (CLL) cells. To obtain new insights into the function of the IL-4 pathway in CLL, we analyzed the gene expression response to IL-4 in CLL and in normal B cells (NBC) by oligonu...

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Bibliographic Details
Main Authors: Natalia Ruiz-Lafuente, María-José Alcaraz-García, Silvia Sebastián-Ruiz, Joaquín Gómez-Espuch, Consuelo Funes, José-María Moraleda, María-Carmen García-Garay, Natividad Montes-Barqueros, Alfredo Minguela, María-Rocío Álvarez-López, Antonio Parrado
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4184842?pdf=render

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http://europepmc.org/articles/PMC4184842?pdf=render

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