One-pot stereoselective synthesis of α,β-differentiated diamino esters via the sequence of aminochlorination, aziridination and intermolecular SN2 reaction

One-pot stereoselective synthesis of α,β-differentiated diamino esters via the sequence of aminochlorination, aziridination and intermolecular SN2 reaction

We report here an efficient one-pot method for the synthesis of α,β-differentiated diamino esters directly from cinnamate esters using N,N-dichloro-p-toluenesulfonamide and benzylamine as nitrogen sources. The key transformations include a Cu-catalyzed aminohalogenation and aziridination, followed b...

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Bibliographic Details
Main Authors: Yiwen Xiong, Ping Qian, Chenhui Cao, Haibo Mei, Jianlin Han, Guigen Li, Yi Pan
Format: Article
Language:English
Published: Beilstein-Institut 2014-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
aminohalogenation
diamination
α,β-diamino ester
one-pot
stereoselectivity
Online Access:https://doi.org/10.3762/bjoc.10.189

Internet

https://doi.org/10.3762/bjoc.10.189

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