Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein

Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein

Abstract Glial cytoplasmic inclusions (GCIs) containing aggregated and hyperphosphorylated α-synuclein are the signature neuropathological hallmark of multiple system atrophy (MSA). Native α-synuclein can adopt a prion conformation that self-propagates and spreads throughout the brain ultimately res...

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Bibliographic Details
Main Authors: Zuzana Krejciova, George A. Carlson, Kurt Giles, Stanley B. Prusiner
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Acta Neuropathologica Communications
Subjects:
MSA
Prion
Astrocytes
α-Synuclein
Proteinopathies
Online Access:http://link.springer.com/article/10.1186/s40478-019-0703-9

Internet

http://link.springer.com/article/10.1186/s40478-019-0703-9

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