Oligonucleotide Tagging for Copper-Free Click Conjugation

Oligonucleotide Tagging for Copper-Free Click Conjugation

Copper-free click chemistry between cyclooctynes and azide is a mild, fast and selective technology for conjugation of oligonucleotides. However, technology for site-specific introduction of the requisite probes by automated protocols is scarce, while the reported cyclooctynes are large and hydropho...

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Bibliographic Details
Main Authors: Alan Rowan, Floris L. van Delft, John C. Hodges, Nancy S. Barta, Brian Gibson, Anup M. Jawalekar, Jorge M. M. Verkade, Sudip Malik
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
copper-free click
oligonucleotide conjugation
bicyclononyne
azide
strain-promoted cycloaddition
Online Access:http://www.mdpi.com/1420-3049/18/7/7346

Internet

http://www.mdpi.com/1420-3049/18/7/7346

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