Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells.

Lymphangioleiomyomatosis (LAM) is a devastating lung disease caused by inactivating gene mutations in either TSC1 or TSC2 that result in hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1). As LAM occurs predominantly in women during their reproductive age and is exacerbated by...

Full description

Bibliographic Details
Main Authors: Yiyang Lu, Xiaolei Liu, Erik Zhang, Elizabeth J Kopras, Eric P Smith, Aristotelis Astreinidis, Chenggang Li, Yuet-Kin Leung, Shuk-Mei Ho, Jane J Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228894