T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment

T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment

Background We previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune activation of the sentinel lymph node (SLN), increased melanoma-specific CD8+ T cell rates in peripheral blood, and prolonged recurrence-free surviva...

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Bibliographic Details
Main Authors: Tanja D de Gruijl, M Petrousjka van den Tol, Bas D Koster, Rik J Scheper, Barbara G Molenkamp, Alfons JM van den Eertwegh, Mari FCM van den Hout, Berbel JR Sluijter, Paul AM van Leeuwen, Marta López González, Annelies W Turksma, Saskia Vosslamber, Ekaterina J Jordanova
Format: Article
Language:English
Published: BMJ Publishing Group 2021-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/3/e001962.full

Internet

https://jitc.bmj.com/content/9/3/e001962.full

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