RNAi reduces expression and intracellular retention of mutant cartilage oligomeric matrix protein.

RNAi reduces expression and intracellular retention of mutant cartilage oligomeric matrix protein.

Mutations in cartilage oligomeric matrix protein (COMP), a large extracellular glycoprotein expressed in musculoskeletal tissues, cause two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal dysplasia. These mutations lead to massive intracellular retention of COMP, chondrocyte death...

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Bibliographic Details
Main Authors: Karen L Posey, Peiman Liu, Huiqiu R Wang, Alka C Veerisetty, Joseph L Alcorn, Jacqueline T Hecht
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2858657?pdf=render

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http://europepmc.org/articles/PMC2858657?pdf=render

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