ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation

ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation

ADAR (adenosine deaminase acting on RNA) catalyzes the deamination of adenosine to generate inosine, through its binding to double-stranded RNA (dsRNA), a phenomenon known as RNA editing. One of the functions of ADAR1 is suppressing the type I interferon (IFN) response, but its mechanism in gastric...

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Bibliographic Details
Main Authors: Lushang Jiang, Min Ji Park, Charles J. Cho, Kihak Lee, Min Kyo Jung, Chan Gi Pack, Seung-Jae Myung, Suhwan Chang
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
RNA editing
gastric cancer
ADAR1
microRNA-302a
type I interferon
IRF9
Online Access:https://www.mdpi.com/1422-0067/21/17/6195

Internet

https://www.mdpi.com/1422-0067/21/17/6195

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