Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee

Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee

Human monoclonal antibody CH58 isolated from an RV144 vaccinee binds at Lys169 of the HIV-1 Env gp120 V2 region, a site of vaccine-induced immune pressure. CH58 neutralizes HIV-1 CRF_01 AE strain 92TH023 and mediates ADCC against CD4+ T cell targets infected with CRF_01 AE tier 2 virus. CH58 and oth...

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Bibliographic Details
Main Authors: Nathan I. Nicely, Kevin Wiehe, Thomas B. Kepler, Frederick H. Jaeger, S. Moses Dennison, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, Merlin L. Robb, Robert J. O'Connell, Nelson L. Michael, Jerome H. Kim, Hua-Xin Liao, S. Munir Alam, Kwan-Ki Hwang, Mattia Bonsignori, Barton F. Haynes
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:EBioMedicine
Subjects:
HIV-1
Gp120
V2
RV-144
Antibody maturation
Germline
Unmutated ancestor
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415300451

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http://www.sciencedirect.com/science/article/pii/S2352396415300451

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