Persistent hepatitis B viral replication in a FVB/N mouse model: impact of host and viral factors.

The mechanism underlying the chronicity of hepatitis B virus (HBV) infection has long been an interesting question. However, this mechanism remains unclear largely due to the lack of an animal model that can support persistent HBV replication and allow for the investigation of the relevant immune re...

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Bibliographic Details
Main Authors: Shih-Hui Chen, Hui-Lin Wu, Jia-Horng Kao, Lih-Hwa Hwang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3353969?pdf=render