Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS

Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS

Abstract Background Cells taken from mouse embryos before sex differentiation respond to insults according to their chromosomal sex, a difference traceable to differential methylation. We evaluated the mechanism for this difference in the controlled situation of their response to ethanol. Methods We...

Full description

Bibliographic Details
Main Authors: Carlos G. Penaloza, Mayra Cruz, Gabrielle Germain, Sidra Jabeen, Mohammad Javdan, Richard A. Lockshin, Zahra Zakeri
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cell Communication and Signaling
Subjects:
Sex differences
Cyp450
ROS
Cell death
Methylation
Online Access:http://link.springer.com/article/10.1186/s12964-020-00616-8

Internet

http://link.springer.com/article/10.1186/s12964-020-00616-8

Similar Items