Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy

Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy

This study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n = 661) from 11 DENV genotypes in 10 endemic coun...

Full description

Bibliographic Details
Main Authors: Maia A Rabaa, Yves Girerd-Chambaz, Kien Duong Thi Hue, Trung Vu Tuan, Bridget Wills, Matthew Bonaparte, Diane van der Vliet, Edith Langevin, Margarita Cortes, Betzana Zambrano, Corinne Dunod, Anh Wartel-Tram, Nicholas Jackson, Cameron P Simmons
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
dengue virus
molecular epidemiology
dengue vaccine
virus evolution
genotype
vaccine
Online Access:https://elifesciences.org/articles/24196

Internet

https://elifesciences.org/articles/24196

Similar Items