TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, using [125I]-epibatidine binding, whole-cell patch-clamp recordings,...

Full description

Bibliographic Details
Main Authors: Teagan R. Wall, Brandon J. Henderson, George Voren, Charles R. Wageman, Purnima Deshpande, Bruce N. Cohen, Sharon R. Grady, Michael J. Marks, Daniel Yohannes, Paul J. Kenny, Merouane Bencherif, Henry A. Lester
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
nicotine addiction
nicotinic acetylcholine receptors
neuroprotection
electrophysiology
transmitter release
α6β2∗
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00641/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00641/full

Similar Items