Phospho-HDAC6 Gathers Into Protein Aggregates in Parkinson’s Disease and Atypical Parkinsonisms

Phospho-HDAC6 Gathers Into Protein Aggregates in Parkinson’s Disease and Atypical Parkinsonisms

HDAC6 is a unique histone deacetylase that targets cytoplasmic non-histone proteins and has a specific ubiquitin-binding activity. Both of these activities are required for HDAC6-mediated formation of aggresomes, which contain misfolded proteins that will ultimately be degraded via autophagy. HDAC6...

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Bibliographic Details
Main Authors: Samanta Mazzetti, Mara De Leonardis, Gloria Gagliardi, Alessandra Maria Calogero, Milo Jarno Basellini, Laura Madaschi, Ilaria Costa, Francesca Cacciatore, Sonia Spinello, Manuela Bramerio, Roberto Cilia, Chiara Rolando, Giorgio Giaccone, Gianni Pezzoli, Graziella Cappelletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
HDAC6
phosphorylated-HDCA6
protein aggregation
α-synuclein
tau
Parkinson’s disease
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00624/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00624/full

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