Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling

Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling

Background/Aims: Multiple exposures to anesthesia in children may increase the risk of developing cognitive impairment. Sevoflurane is an anesthetic that is commonly used in children during surgery. Cyclin-dependent kinase (CDK) 5 is involved in the regulation of sevoflurane-induced cognitive dysfun...

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Bibliographic Details
Main Authors: Jianhui Liu, Junjun Yang, Yinhua Xu, Gang Guo, Li Cai, Heng Wu, Yanhong Zhao, Xiaoqing Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Sevoflurane
Cognitive dysfunction
CDK5
Tau
PPARγ
Online Access:https://www.karger.com/Article/FullText/485008

Internet

https://www.karger.com/Article/FullText/485008

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