Identification of the Merkel Cell Polyomavirus Large Tumor Antigen Ubiquitin Conjugation Residue

Identification of the Merkel Cell Polyomavirus Large Tumor Antigen Ubiquitin Conjugation Residue

Merkel cell polyomavirus (MCPyV) large tumor (LT) antigen is a DNA binding protein essential for viral gene transcription and genome replication. MCPyV LT interacts with multiple E3 ligases in a phosphorylation-dependent manner, limiting its own viral replication by enhancing LT protein degradation,...

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Bibliographic Details
Main Authors: Luz E. Ortiz, Alexander M. Pham, Hyun Jin Kwun
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
Merkel cell polyomavirus
Merkel cell carcinoma
large tumor antigen
Ubiquitination
ATPase activity
Polyomavirus replication
Online Access:https://www.mdpi.com/1422-0067/22/13/7169

Internet

https://www.mdpi.com/1422-0067/22/13/7169

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