Transfer of Synthetic Human Chromosome into Human Induced Pluripotent Stem Cells for Biomedical Applications

Transfer of Synthetic Human Chromosome into Human Induced Pluripotent Stem Cells for Biomedical Applications

Alphoid<sup>tetO</sup>-type human artificial chromosome (HAC) has been recently synthetized as a novel class of gene delivery vectors for induced pluripotent stem cell (iPSC)-based tissue replacement therapeutic approach. This HAC vector was designed to deliver copies of genes into patie...

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Bibliographic Details
Main Authors: Sergey A. Sinenko, Elena V. Skvortsova, Mikhail A. Liskovykh, Sergey V. Ponomartsev, Andrey A. Kuzmin, Aleksandr A. Khudiakov, Anna B. Malashicheva, Natalia Alenina, Vladimir Larionov, Natalay Kouprina, Alexey N. Tomilin
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cells
Subjects:
human artificial chromosome (HAC)
alphoid<sup>tetO</sup>-HAC
induced pluripotent stem cells (iPSCs)
microcell-mediated chromosome transfer (MMCT)
cell reprogramming
Online Access:https://www.mdpi.com/2073-4409/7/12/261

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https://www.mdpi.com/2073-4409/7/12/261

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